| Heptafluorobutyric acid | |
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2,2,3,3,4,4,4-Heptafluorobutanoic acid |
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Other names
Heptafluorobutanoic acid; Perfluorobutanoic acid; Perfluorobutyric acid |
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| Identifiers | |
| Abbreviations | HFBA |
| CAS number | 375-22-4 |
| PubChem | 9777 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C4HF7O2 |
| Molar mass | 214.04 g mol−1 |
| Appearance | colourless liquid |
| Density | 1.64 g/ml |
| Boiling point |
120 °C |
| Solubility in water | high |
| Hazards | |
| Main hazards | strong acid |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Heptafluorobutyric acid (HFBA) is an organofluorine compound with the formula C3F7CO2H. As the fluorinated derivative of butyric acid, this colourless liquid is prepared by electrofluorination of the corresponding butyryl fluoride.[1]
HFBA has a variety of niche applications in analytical and synthetic chemistry. It is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides.
Esters derived from HFBA readily undergo condensation, owing to their electrophilicity. Specialized ligands for metal ions are generated capitalizing on this property, such as Eufod.